Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3920 | CA37720 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 72 |
| 2 | AZT+DDC | 134 |
| 3 | 3TC+D4T | 36 |
| 4 | 3TC+AZT+IDV | 16 |
| 5 | 3TC+AZT+NFV | 46 |
| 6 | NVP+3TC+D4T+NFV | 62 |
| 7 | ABC+DDI+RTV+SQV | 34 |
| 8 | Unknown | 10 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33F | N37CS, P39PS, I62V, I64V, V77I |
| >CA37720| codons 7-98 QRPLVTIKIGGQLKEALLDTGADDTVFEEMSLSGRWKPKMIGGIGGFIKVRQYDQVLVEI CGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | V35M, K104N, K166R, G196E, H208Y, R211K, D218E, V245T, E248D, D250E, A272P, R284RK, T286A, E297K, D324E, Q334E, M357T, G359GS, K366R, A371AV, I375IV, A376T, K390R, A400T, V417VI, V435E, K451R, L452S, D460N, T470N, K476KR, K512R, S519N | Q197T, L551LS |
| >CA37721| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIETHRTKIEELRQYLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPITLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVRQLTEVVQKVTTESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFINTP PLVKLWYQLEKEPIEGAETFYVDGAANRETRSGKAGYVTNRGRQKVVSLNDTTNQRTELQ AIHLALQDSGLEVNIVTDSQYALGIIQAQPDRSESELVNQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKSVSAGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |