Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7917 | CA37714 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 104 |
| 2 | 3TC+AZT+SQV | 61 |
| 3 | 3TC+AZT+D4T+IDV | 48 |
| 4 | D4T+DDI+NVP+RTV+SQV | 8 |
| 5 | D4T+DDI+IDV+RTV | 48 |
| 6 | APV+D4T+DDI+EFV | 57 |
| 7 | APV+D4T+DDI+RTV | 144 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47V, G48V, I54M, V82A, L90M | L10I, T12S, I13V, G16A, Q18H, K20I, L63P, A71IV, I85V, I93L |
| >CA37714| codons 1-99 PQITLWQRPIVSVKIAGHLIEALLDTGADDTVLEEMNLPGRWKPKMVVGIGGFMKVRQYD QIPIEICGHKVIGTVLVGPTPANIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M | F116Y, K219Q | T39TA, V60I, V118I, K122E, I135T, T139I, K166Q, G196E, T200I, F214L, L228H, A272P, E291D |
| >CA37715| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSIPL DEDFRKYTAFTIPSTNNEIPGIRYQYNVLPMGWKGSPAIFQSSMTQILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRIKIEELRQHLLRWGLTTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVIPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |