Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1529 | CA37666 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 39 |
| 2 | D4T | 57 |
| 3 | 3TC+D4T | 30 |
| 4 | 3TC+D4T+IDV | 22 |
| 5 | 3TC+D4T+NFV | 35 |
| 6 | 3TC+D4T+NVP | 15 |
| 7 | D4T+DDI+RTV+SQV | 15 |
| 8 | D4T+DDI | 71 |
| 9 | ABC+D4T+NVP | 86 |
| 10 | ABC+D4T | 96 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, N37S, R57K, L63P, A71T, V77I |
| >CA37666| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKTIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69E_G, V75VIM, L210W, T215Y | K70KQ | Y188L | A98AG | T39TA, E40X, K43KE, V60I, S68SG, K101KQ, K102KQ, V106IL, V118I, D123E, I135V, S162C, V179VI, G196E, T200A, E203DV, Q207DE, H208HY, R211RK, K223KQ, K238KR, A272AP, T286A, I293V, P313S |
| >CA37667| codons 1-330 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAXLEEEGKISKIGPENPYNTPI FAIKKKNGEQWRKLMDFRELNKRTQDFWEVQLGIPHPGGLQQKKSLTVLDVGDAYFSIPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII YQYMDDLLVGSDLEIEQHRAKIVELREYLWKWGFYTPDKKHQQEPPFLWMGYELHPDRWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKESVHGVYYDPSKDLIAEIQ |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |