Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| apv13 | apv13M4 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC+ NFV | 16 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | E35D, M36I, R41K, I62V, L63P, V77I, I93L |
| >apv13M4| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | A62V, D67G | R83K, I135T, S162C, Q174H, D177E, G196E, Q197K |
| >apv13M4| codons 40-239 EMEKEGKISKIGPENPYNTPVFVIKKKGSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAG LKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAI FQCSMTKILEPFRKHNPEIVIYQYVDDLYVGSDLEIEKHRTKIEELRQHLLRWGFTTPDK KHQKEPPFLWMGYELHPDKW |
References
| Author | Title | Citation |
| Masquelier, B | Mechanisms of early virologic failure in antiretroviral-naive patients starting protease inhibitor-containing regimens: the APROVIR study. | J Infect Dis, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |