Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| apv10 | apv10M8 | France | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ DDI+ NFV | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | K20R, R57K, I62V, L63P, A71T, V77I, I93L |
| >apv10M8| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKTIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q207E |
| >apv10M8| codons 32-239 KALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQ LGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQ GWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELREHLLR WGFTTPDKKHQKEPPFLWMGYELHPDKW |
References
| Author | Title | Citation |
| Masquelier, B | Mechanisms of early virologic failure in antiretroviral-naive patients starting protease inhibitor-containing regimens: the APROVIR study. | J Infect Dis, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |