Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
apv8 | apv8M8 | France | 1999 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT+ 3TC+ NFV | 32 |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
D30N | I13V, K14R, G17E, K20R, E35D, M36I, N37E, L63P |
>apv8M8| codons 1-99 PQITLWQRPLVTVRIGEQLREALLDTGADNTVLEDIELPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M184V | V35VI, K49R, R83K, D123E, I135T, T200TI, I202IV, V245E |
>apv8M8| codons 1-255 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRIKVEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVN |
References
Author | Title | Citation |
Masquelier, B | Mechanisms of early virologic failure in antiretroviral-naive patients starting protease inhibitor-containing regimens: The APROVIR study. | J Infect Dis, 2002 |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |