<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
apv2 apv2M4 France 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T+ DDI+ NFV 16

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N   I15V, N37S, R57K, D60E, Q61E, L63P, I93L  
>apv2M4| codons 1-99
PQITLWQRPLVTIKVGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVKQYE
EIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        T7S, K64R, T69A, A98S, D123E, I135T, S162A, D177E, Q207E, L210S  
>apv2M4| codons 1-255
PISPIESVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIRKKDSAKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLSRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVN

References
Author Title Citation
Masquelier, B Mechanisms of early virologic failure in antiretroviral-naive patients starting protease inhibitor-containing regimens: The APROVIR study. J Infect Dis, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005