Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| apv2 | apv2M4 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ DDI+ NFV | 16 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | I15V, N37S, R57K, D60E, Q61E, L63P, I93L |
| >apv2M4| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVKQYE EIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T7S, K64R, T69A, A98S, D123E, I135T, S162A, D177E, Q207E, L210S |
| >apv2M4| codons 1-255 PISPIESVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIRKKDSAKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLSRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVN |
References
| Author | Title | Citation |
| Masquelier, B | Mechanisms of early virologic failure in antiretroviral-naive patients starting protease inhibitor-containing regimens: the APROVIR study. | J Infect Dis, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |