<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
apv1 apv1M12 France 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T+ 3TC+ NFV 52

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N N88D I15V, E35D, M36MI, N37S, R57K, D60E, I62V, L63P L23LF, I93NT
>apv1M12| codons 1-99
PQITLWQRPLVTIKVGGQLKEAFLDTGADNTVLEDISLPGRWKPKMIGGIGGFIKVKQYE
QVPIEICGHKAIGTVLVGPTPVNIIGRDLLTQNGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T215Y       A98S, V118VA, D123E, I135V, S162A, D177E, I178V, E203D, R211K  
>apv1M12| codons 14-243
PGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRK
LVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSAPLDKEFRKYTAFTIP
SVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEVVIYQYMDDLYVGSDL
EIGQHRTKIDELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQP

References
Author Title Citation
Masquelier, B Mechanisms of early virologic failure in antiretroviral-naive patients starting protease inhibitor-containing regimens: The APROVIR study. J Infect Dis, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005