Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| apv1 | apv1M12 | France | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ 3TC+ NFV | 52 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | I15V, E35D, M36MI, N37S, R57K, D60E, I62V, L63P | L23LF, I93NT |
| >apv1M12| codons 1-99 PQITLWQRPLVTIKVGGQLKEAFLDTGADNTVLEDISLPGRWKPKMIGGIGGFIKVKQYE QVPIEICGHKAIGTVLVGPTPVNIIGRDLLTQNGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | A98S, V118VA, D123E, I135V, S162A, D177E, I178V, E203D, R211K |
| >apv1M12| codons 14-243 PGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRK LVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSAPLDKEFRKYTAFTIP SVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEVVIYQYMDDLYVGSDL EIGQHRTKIDELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQP |
References
| Author | Title | Citation |
| Masquelier, B | Mechanisms of early virologic failure in antiretroviral-naive patients starting protease inhibitor-containing regimens: the APROVIR study. | J Infect Dis, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |