Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| apv1 | apv1M10 | France | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ 3TC+ NFV | 40 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | L10I, N37S, R57K, L63P, I93L |
| >apv1M10| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | A98S, D123E, S162A, D177E, T200P, Q207G | T128TA |
| >apv1M10| codons 13-242 KPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWR KLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPLDKEFRKYAAFTI PSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEIVIYQYVDDLYVGSD LEIGQHRPKIEELRGHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQ |
References
| Author | Title | Citation |
| Masquelier, B | Mechanisms of early virologic failure in antiretroviral-naive patients starting protease inhibitor-containing regimens: the APROVIR study. | J Infect Dis, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |