Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-43 | AS-43 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | DLV | 40 |
| 2 | None | 45 |
| 3 | 3TC+D4T+NFV | 75 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33V, R41K, L63Q, I64V |
| >AS-43| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-43| C1 | codons 1-99 | clone C1 PQITLWQRPLVTIKIGGQPKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-43| C2 | codons 1-99 | clone C2 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-43| C3 | codons 1-99 | clone C3 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-43| C4 | codons 1-99 | clone C4 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIRVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-43| C5 | codons 1-99 | clone C5 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-43| C6 | codons 1-99 | clone C6 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-43| C7 | codons 1-99 | clone C7 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-43| C8 | codons 1-99 | clone C8 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | V35E, T39A, S48T, V60I, S162C, K166R, G196E, Q207E |
| >AS-43| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-43| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAEMEKEGEITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQCMDDLYVGSDLEIEQHRTKIEELREHLLRWGFTTPDKXHQKEPPFLW >AS-43| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELRKHLLRWGFTTPDKKHQKEPPFLW >AS-43| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAEMEKEGKITKIGPENPYNTPI FAIRKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRKQNPDIII YQYMDDLYVGSDLEIE*HRTKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-43| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKTLEEICAEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-43| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-43| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-43| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYDVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-43| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRKQNLDIII YQYMDDLYVGSDLEIEQHRTKIEELGEHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |