Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-41 | AS-41 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+3TC+NFV | 68 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | I15V, K20T, M36I, D60E, I62V, T74A, L89I |
| >AS-41| codons 1-99 PQITLWQRPLVTIKVGGQLTEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYE QVLIEICGHKAIGAVLVGPTPVNIIGRNIMTQIGCTLNF >AS-41| C1 | codons 1-99 | clone C1 PQITLWQRPFVTVKVGGQLTEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYE QVLIEICGHKAIGAVLVGPTPVNIIGRNIMTQIGCTLNF >AS-41| C2 | codons 1-99 | clone C2 PQITLWQRPLVTVKVGGQLTEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYE QVLIEICGHKAIGTVLVGPTPVNIIGRNIMTQIGCTLNF >AS-41| C3 | codons 1-99 | clone C3 PQITLWQRPLVTVKVGGQLTEALLDTGADDTVLEEITLPGRWKPKMIGGIGGFIKVRQYE QVLIEICGHKAIGAVLVGPTPVNIIGRNIMTQIGCTLNF >AS-41| C4 | codons 1-99 | clone C4 PQITLWQRPFVTVKVGGQLTEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYE QVLIEICGHKAIGAVLVGPTPVNIIGRNIMTQIGCTLNF >AS-41| C5 | codons 1-99 | clone C5 PQITLWQRPLVTVKVGGQLTEALLDTGADDTVLEGINLPGRWKPKMIGGIGGFIKVRQYE QVLIEICGHKAIGTVLVGPTPVNIIGRNIMTQIGCTLNF >AS-41| C6 | codons 1-99 | clone C6 PQITLWQRPLVTVKVGGQLTEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYE QVLIEICGHKAIGAVLVGPTPVNIIGRNIMTQIGCTLNF >AS-41| C7 | codons 1-99 | clone C7 PQITLWQRPLVTVRVGGQLTEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYE QVLIEICGHKAIGTVLVGPTPVNIIGRNIMTQIGCTLNF >AS-41| C8 | codons 1-99 | clone C8 PQITLWQRPLVTVKVGGQLTEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYE QVLIEICGHKAIGAVLVGPTPVNIIGRNIMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K20R, T27S, K122E, I135T, I142M, F214L |
| >AS-41| codons 1-229 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGMRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-41| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALEEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSAPL DEDFRKYTAFTIPSTNNETPGMRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-41| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGMRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-41| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGMRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-41| C4 | codons 1-229 | clone C4 PISPIETVPVELKPGMDGPKVKQWPLSEEKIKALVEICTEMEKEGKISKIGPENLYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTMPSTNNETPGMRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-41| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGMRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-41| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGMRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLGWGLTTPDKKHQKEPPFLW >AS-41| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDTYFSVPL DEDFRKYTAFTIPSTNNETPGMRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-41| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPKVKQWPLSEEKMKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFREVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGMRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |