<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1138 CA3736 U.S. 1997 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 100
2 None 31
3 D4T 22
4 None 31
5 3TC+AZT+SQV 26
6 3TC+D4T+IDV 54
7 3TC+D4T+DDI+RTV+SQV 21

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V82F   K14R, L19Q, E35D, N37T, L63P, A71T  
>CA3736| codons 1-99
PQITLWQRPLVTIRIGGQQKEALLDTGADDTVLEDMTLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKTIGTVLVGPTPFNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70R, M184V       E6K, K103R, K122E, I135L, Q207E, R211K, V245E, T286A, E297K K281KE
>CA3735| codons 1-300
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCELLRGAKALTEVIPLTKEAE

References
Author Title Citation
Kantor, R Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. AAC, 2002
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005