Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-40 | AS-40 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC | 34 |
| 2 | AZT+NFV+3TC | 30 |
| 3 | 3TC+AZT+NFV | 36 |
| 4 | 3TC+D4T+NFV | 13 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | Q58E | L19I, K20T, M36I, I62V, L63S, I64V, V77I, I93L |
| >AS-40| codons 1-99 PQITLWQRPLVTIKIGGQITEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVREYD QVSVEICGHKAIGTVLIGPTPVNIIGRNLMTQLGCTLNF >AS-40| C1 | codons 1-99 | clone C1 PQITLWQRPLVTVKIGGQLTEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIRVREYD QVSVEICGHKAIGTVLIGPTPVNIIGRNLMTQLGCTLNF >AS-40| C2 | codons 1-99 | clone C2 PQITLWQRPLVTIKIGGQMIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYE QVSVEICGHKVIGTVLIGPTPVNIIGRNLMTQLGCTLNF >AS-40| C3 | codons 1-99 | clone C3 PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD QVSVEICGHKAIGSVLIGPTPVNIIGRNLMTQLGCTLNF >AS-40| C4 | codons 1-99 | clone C4 PQITLWQRPLVTIKIGGQIIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVREYD QVSVEICGHKATGTVLIGPTPVNIIGRNLMTQLGCTLNF >AS-40| C5 | codons 1-99 | clone C5 PQITLWQRPLVTIKIGGQIIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVREYD QVSVEICGHKAIGTVLIGPTPVNIIGRNLMTQLGCTLNF >AS-40| C6 | codons 1-99 | clone C6 PQITLWQRPLVTIKIGGQIIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVREYD QVSVEICGHKATGTVLIGPTPVNIIGRNLMTQLGCTLNF >AS-40| C7 | codons 1-99 | clone C7 PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD QVSVEICGHKAIGTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | R83K, K102Q, T200A |
| >AS-40| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-40| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDLRELNKKTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKNFRKYTAFTIPSINNETPGIKYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLHVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-40| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-40| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIEKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFPW >AS-40| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPGNPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-40| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVNDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-40| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHPLRWGFTTPDKKHQKEPPFLW >AS-40| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |