Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-38 | AS-38 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+3TC+NFV | 33 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L | L10F, T74P | T12I, I15V, L19T, L63T, I72V |
| >AS-38| codons 1-99 PQITLWQRPFVIIKVGGQTKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGPVLVGPTPVNIIGRNLLTQIGCTLNF >AS-38| C1 | codons 1-99 | clone C1 PQITLWQRPFVIIKVGGQTKEALLDTGADGTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGSVLVGPTPVNIIGRNLMTQIGCTLNF >AS-38| C2 | codons 1-99 | clone C2 PQITLWQRPFVIIKIGGQTKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGSVLVGPTPVNIIGRNLMTQIGCTLNF >AS-38| C3 | codons 1-99 | clone C3 PQITLWRRPFVIIKVGGQTKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGPVLVGPTPVNIIGRNLLTQIGCTLNF >AS-38| C4 | codons 1-99 | clone C4 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYE QIPIEICGQKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-38| C5 | codons 1-99 | clone C5 PQITLWQRPLVIIKVGGQTKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGAVLVGPTPFNIIGRNLLTQIGRTLNF >AS-38| C6 | codons 1-99 | clone C6 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIRVRQYE QIPIEICGHKAISTVLVGPTPVNIIGRNLLTRLGCTLNF >AS-38| C7 | codons 1-99 | clone C7 PQITLWQRPFVIIKVEGQTKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGPVLVGPTPVNIIGRNLLTQIGCTLNF >AS-38| C8 | codons 1-99 | clone C8 PQITLWQRPFVIIKVEGQTKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGSVLVGPTPVNIIGRNLMTQIGCTLNF >AS-38| C9 | codons 1-99 | clone C9 PQITLWQRPFVIIKVEGQTKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGPVLVGPTPVNIIGRNLLTQIGCTLNF >AS-38| C10 | codons 1-99 | clone C10 PQITLWQRPFVIIKVEGQTKEALLDTGADDTVLEEMNLPGRWKPKLIGEIGGFIKVRQYD QITIEICGHKAVGPVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K20R, K49R, E169D, G196R, T200E, Q207E |
| >AS-38| codons 1-229 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIRQHREKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-38| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIRQHREKIEELRKHLLR*GFTTPDKKHQKEPPFLW >AS-38| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFGELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIRQHREKIEELREHLLRWGFTTPDKKRQKEPPFLW >AS-38| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIRQHREKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-38| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDLWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVV YQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-38| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIRQHREKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-38| C6 | codons 1-229 | clone C6 PISPVETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKEKKSVTVLDVGDAYFSVPL DKDFRKHTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRQHLLRWGFFTPEQKHQKEPPFHW >AS-38| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIRQHREKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-38| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYLSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIRQHREKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-38| C9 | codons 1-229 | clone C9 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIRQHREKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-38| C10 | codons 1-229 | clone C10 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLTDFRELNKRTQDFWEVQLGIPHPAGLRKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI Y*YVDDLYVGSDLEIRQHREKVEELREHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |