Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-37 | AS-37 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC | 52 |
| 2 | 3TC+AZT+NFV | 1 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | T12P, L19I, K20I, M36V, N37D, L63P, A71V, I93L |
| >AS-37| codons 1-99 PQITLWQRPLVPIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF >AS-37| C1 | codons 1-99 | clone C1 PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF >AS-37| C2 | codons 1-99 | clone C2 PQITLWQRPLVPVKIGGQMREALLDTGADDTVVEEINLPGKWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >AS-37| C3 | codons 1-99 | clone C3 PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF >AS-37| C4 | codons 1-99 | clone C4 PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKITGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF >AS-37| C5 | codons 1-99 | clone C5 PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF >AS-37| C6 | codons 1-99 | clone C6 PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPVNMIGRNLMTQLGCTLNF >AS-37| C7 | codons 1-99 | clone C7 PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF >AS-37| C8 | codons 1-99 | clone C8 PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKIIG*IGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF >AS-37| C9 | codons 1-99 | clone C9 PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215Y | R211K |
| >AS-37| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-37| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPGKKHQKEPPFLW >AS-37| C2 | codons 1-229 | clone C2 PISPIETVPVKLRPGMDGPKVKQWPSTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTRIEELRQHLLKWGFITPDEKHQKEPPFLW >AS-37| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-37| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-37| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLAEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFREPNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-37| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-37| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHGTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-37| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DTDFRKYTAFTIPSINNETPGIRYQYNVLPRGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHKTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-37| C9 | codons 1-229 | clone C9 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKRNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWXGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |