<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
AS-37 AS-37 U.S. 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+3TC 52
2 3TC+AZT+NFV 1

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M   T12P, L19I, K20I, M36V, N37D, L63P, A71V, I93L  
>AS-37| codons 1-99
PQITLWQRPLVPIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF
>AS-37| C1 | codons 1-99 | clone C1
PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF
>AS-37| C2 | codons 1-99 | clone C2
PQITLWQRPLVPVKIGGQMREALLDTGADDTVVEEINLPGKWKPKMIGGIGGFIKVRQYD
QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF
>AS-37| C3 | codons 1-99 | clone C3
PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF
>AS-37| C4 | codons 1-99 | clone C4
PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKITGGIGGFIKVRQYD
QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF
>AS-37| C5 | codons 1-99 | clone C5
PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF
>AS-37| C6 | codons 1-99 | clone C6
PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKVIGTVLVGPTPVNMIGRNLMTQLGCTLNF
>AS-37| C7 | codons 1-99 | clone C7
PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF
>AS-37| C8 | codons 1-99 | clone C8
PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKIIG*IGGFIKVRQYD
QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF
>AS-37| C9 | codons 1-99 | clone C9
PQITLWQRPLVNIKIGGQIIEALLDTGADDTVLEEVDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V, T215Y       R211K  
>AS-37| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW
>AS-37| C1 | codons 1-229 | clone C1
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPGKKHQKEPPFLW
>AS-37| C2 | codons 1-229 | clone C2
PISPIETVPVKLRPGMDGPKVKQWPSTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIEQHRTRIEELRQHLLKWGFITPDEKHQKEPPFLW
>AS-37| C3 | codons 1-229 | clone C3
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW
>AS-37| C4 | codons 1-229 | clone C4
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW
>AS-37| C5 | codons 1-229 | clone C5
PISPIETVPVKLKPGMDGPKVKQWPLAEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFREPNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW
>AS-37| C6 | codons 1-229 | clone C6
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW
>AS-37| C7 | codons 1-229 | clone C7
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHGTKIEELRQHLLKWGFYTPDKKHQKEPPFLW
>AS-37| C8 | codons 1-229 | clone C8
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DTDFRKYTAFTIPSINNETPGIRYQYNVLPRGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHKTKIEELRQHLLKWGFYTPDKKHQKEPPFLW
>AS-37| C9 | codons 1-229 | clone C9
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKRNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWXGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW

References
Author Title Citation
Saah, AJ Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. J Infect Dis, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005