Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-36 | AS-36 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NFV+AZT+3TC | 41 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L10I, N37D, D60E, L63P, I66F, A71T, I72L, V77I |
| >AS-36| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYE QIPIEFCGHKTLGTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-36| C1 | codons 1-99 | clone C1 PQITLLQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYE QIPIEICGHKTLSTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-36| C2 | codons 1-99 | clone C2 PQITLWQRPIVTIEIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYE QIPIEFCGHKILGTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-36| C3 | codons 1-99 | clone C3 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYE QIPIEICGHKTLSTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-36| C4 | codons 1-99 | clone C4 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRRYE QIPIEICGHKTLSTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-36| C5 | codons 1-99 | clone C5 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYE QIPIEFCGHKTLGTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-36| C6 | codons 1-99 | clone C6 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYE QIPIEFCGHKILGTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-36| C7 | codons 1-99 | clone C7 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYE QIPIEFCGHKILGTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | E6K, V60I, V118I, K122E, D123E, I135T, G196E, Q197K, T200I, F214L |
| >AS-36| codons 1-229 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEKHRIKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-36| C1 | codons 1-229 | clone C1 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGEISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEKHRIKIEELRQHLLRWGLTTPDKKHQEEPPFLW >AS-36| C2 | codons 1-229 | clone C2 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSTPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEKHRIKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-36| C3 | codons 1-229 | clone C3 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGKHRIKIEELRQHLLRWGLTTPDKKHQEEPPFLW >AS-36| C4 | codons 1-229 | clone C4 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVT YQYVDDLYVGSDLEIEKHRIKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-36| C5 | codons 1-229 | clone C5 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEKHRIKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-36| C6 | codons 1-229 | clone C6 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFGELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEKHRIKIEELRQHLLRWGLTTPDKKHQKEPPFLW >AS-36| C7 | codons 1-229 | clone C7 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEKHRIKIEELRQHLLRWGLTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |