Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-35 | AS-35 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC | 2 |
| 2 | D4T+3TC | 27 |
| 3 | 3TC+D4T+NFV | 52 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | K20I, M36I, K43R, R57K, L63P, A71V |
| >AS-35| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQIGCTLNF >AS-35| C1 | codons 1-99 | clone C1 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD QIPIEICGQKVIGTVLVGPTPVNIIGRNLMTQIGCTLNF >AS-35| C2 | codons 1-99 | clone C2 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD QIPIEICGQKVIGTVLVGPTPVNIIGRNLMTQIGCTLNF >AS-35| C3 | codons 1-99 | clone C3 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD QIPIEICGHKVIGTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-35| C4 | codons 1-99 | clone C4 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLMTQIGCTLNF >AS-35| C5 | codons 1-99 | clone C5 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD QIPIEICGHKVIGTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-35| C6 | codons 1-99 | clone C6 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEISLPGRWRPKMIGGIGGFIKVKQYD QIPIEICGHKIIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V60I, R83K, K122E, D123E, G196E |
| >AS-35| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-35| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDRKHQKEPPFLW >AS-35| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-35| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGTDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEEPGQHLLRWGFTTPDKKHQKEPPFLW >AS-35| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFRSSMTKTLEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-35| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-35| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKEDSTKWRKLVDFRELNKRTQDLWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLGIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |