<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
AS-35 AS-35 U.S. 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+3TC 2
2 D4T+3TC 27
3 3TC+D4T+NFV 52

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M   K20I, M36I, K43R, R57K, L63P, A71V  
>AS-35| codons 1-99
PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD
QIPIEICGHKVIGTVLVGPTPVNIIGRNLMTQIGCTLNF
>AS-35| C1 | codons 1-99 | clone C1
PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD
QIPIEICGQKVIGTVLVGPTPVNIIGRNLMTQIGCTLNF
>AS-35| C2 | codons 1-99 | clone C2
PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD
QIPIEICGQKVIGTVLVGPTPVNIIGRNLMTQIGCTLNF
>AS-35| C3 | codons 1-99 | clone C3
PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD
QIPIEICGHKVIGTVLIGPTPVNIIGRNLMTQIGCTLNF
>AS-35| C4 | codons 1-99 | clone C4
PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRNLMTQIGCTLNF
>AS-35| C5 | codons 1-99 | clone C5
PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFIKVKQYD
QIPIEICGHKVIGTVLIGPTPVNIIGRNLMTQIGCTLNF
>AS-35| C6 | codons 1-99 | clone C6
PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEISLPGRWRPKMIGGIGGFIKVKQYD
QIPIEICGHKIIGTVLVGPTPVNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       V60I, R83K, K122E, D123E, G196E  
>AS-35| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW
>AS-35| C1 | codons 1-229 | clone C1
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDRKHQKEPPFLW
>AS-35| C2 | codons 1-229 | clone C2
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW
>AS-35| C3 | codons 1-229 | clone C3
PISPIETVPVKLKPGTDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEEPGQHLLRWGFTTPDKKHQKEPPFLW
>AS-35| C4 | codons 1-229 | clone C4
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFRSSMTKTLEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW
>AS-35| C5 | codons 1-229 | clone C5
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW
>AS-35| C6 | codons 1-229 | clone C6
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKEDSTKWRKLVDFRELNKRTQDLWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLGIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW

References
Author Title Citation
Saah, AJ Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. J Infect Dis, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005