Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-33 | AS-33 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+3TC | 48 |
| 2 | D4T+NFV+3TC | 14 |
| 3 | 3TC+NFV | 20 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, L19I, K20T, E35G, I64V, T74S, V77I |
| >AS-33| codons 1-99 PQITLWQRPIVTIKIGGQITEALLDTGADDTVLEGMNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGSVLIGPTPVNIIGRNLLTQIGCTLNF >AS-33| C1 | codons 1-99 | clone C1 PQITLWQRPLVTIRIGGQIKEALLDTGADDTVLEDVDLPGRWKPKMIGGIGGFIKVKQYD QILVEICGHKAIGSVLIGPTPVNIIGRNLLTQIGCTLNF >AS-33| C2 | codons 1-99 | clone C2 PQITLWQRPIVTIKIGGQVTEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QVLVEICGHKAIGSVLIGPTPVNIIGRNLLTQIGCTLNF >AS-33| C3 | codons 1-99 | clone C3 PQITLWQRPLVTIRIGGQVTEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGSVLIGPTPVNIIGRNLLTQIGRTLNF >AS-33| C4 | codons 1-99 | clone C4 PQITLWQRPLVTIRIGGQVTEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-33| C5 | codons 1-99 | clone C5 PQITLWQRPIVTIRIGGQVTEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLMTQIGCTLNF >AS-33| C6 | codons 1-99 | clone C6 PQITLWQRPIVTIKIGGQVKEALLDTGADDTVLEDVNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLMTQIGCTLNF >AS-33| C7 | codons 1-99 | clone C7 PQITLWQRPIVTIKIGGQVTEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGSVLIGPTPVNIIGRNLLTQIGCTLNF >AS-33| C8 | codons 1-99 | clone C8 PQITLWQRPIVTIKIGGQVTEAPLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGSVLIGPTPVNIIGRNLLTQIGCTLNF >AS-33| C9 | codons 1-99 | clone C9 PQITLWQRPLVTIKIGGQVTEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGSVLIGPTPVNIIGRNLLTQIGCTLNF >AS-33| C10 | codons 1-99 | clone C10 PQITLWQRPIVTIKIGGQVTEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGSVLIGPTPVNIIGGNLMTQIGCTLNF >AS-33| C11 | codons 1-99 | clone C11 PQITLWQRPIVTIKIGGQVTEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGSVLIEPTPVNIIGRNPLTQLGCTLNF >AS-33| C12 | codons 1-99 | clone C12 PQITLWQLPLVTIRIGGQVTEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QLLVEICGHKAIGSVLIGPTPVNIIGRNLLTQIGCTLNF >AS-33| C13 | codons 1-99 | clone C13 PQITLWQRPIVTIKIGGQVTEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYE QITIEFCGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >AS-33| C14 | codons 1-99 | clone C14 PQITLWQRPLVTIKIGGQGTEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGSVLIGPTPVNIIGRNLLTQIGCTLNF >AS-33| C15 | codons 1-99 | clone C15 PQITLWQRPLVTIRIGGQVTEALLDTGADDTVLEGMNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGSVLIGPTPVNIIGRNLLTQIGCTLNF >AS-33| C16 | codons 1-99 | clone C16 PQITLWQRPLVTIRIGGQVTEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGSVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35I, R83K, D123E, I135T, K166R, R211K |
| >AS-33| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-33| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQRPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-33| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSGLEIGQHRTKIEELRQHLLKWGFTAPDKKHQKEPPFLW >AS-33| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLEWGFTTPDKKHQKEPPFLW >AS-33| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRRHLLKWGFTTPDKKHQKEPPFLW >AS-33| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-33| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-33| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKNHQKEPPFLW >AS-33| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGPDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-33| C9 | codons 1-229 | clone C9 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQSPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-33| C10 | codons 1-229 | clone C10 PTSPIETVPVKLKPGMDGPKVKQWPLTEE*IKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYIAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGLTTPDKKHQKEPPFLW >AS-33| C11 | codons 1-229 | clone C11 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-33| C12 | codons 1-229 | clone C12 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKIPKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFAIPSTTNEPPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRNQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-33| C13 | codons 1-229 | clone C13 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPA FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-33| C14 | codons 1-229 | clone C14 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIRPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDF*EVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQG*KGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVRSDLEIRQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-33| C15 | codons 1-229 | clone C15 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEEKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-33| C16 | codons 1-229 | clone C16 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |