<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
AS-32 AS-32 U.S. 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 308
2 AZT+DDI 4
3 DDI 68
4 None 5
5 NFV 36
6 DDI+NFV 14
7 D4T+NFV 5
8 D4T+DDI+NFV 47

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M Q58E, G73S I13V, K20V, L63P, A71V, V77I  
>AS-32| codons 1-99
PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVREYD
QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF
>AS-32| C1 | codons 1-99 | clone C1
PQITLWQRPLVTVKIGGQLVEAPLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF
>AS-32| C2 | codons 1-99 | clone C2
PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD
QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF
>AS-32| C3 | codons 1-99 | clone C3
PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF
>AS-32| C4 | codons 1-99 | clone C4
PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVREYD
QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF
>AS-32| C5 | codons 1-99 | clone C5
PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVREYD
QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF
>AS-32| C6 | codons 1-99 | clone C6
PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD
QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF
>AS-32| C7 | codons 1-99 | clone C7
PQITLWQRPLVTVRIGGQLVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD
QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF
>AS-32| C8 | codons 1-99 | clone C8
PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD
QIPIEICGHKVIGTVLIGPTPVNIIGRNLMTQIGCTLNF
>AS-32| C9 | codons 1-99 | clone C9
PQITLWQRPLVTIKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, T215Y K219Q     V60I, K104Q, D121Y, K122E, D177E  
>AS-32| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW
>AS-32| C1 | codons 1-229 | clone C1
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW
>AS-32| C2 | codons 1-229 | clone C2
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW
>AS-32| C3 | codons 1-229 | clone C3
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIAI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW
>AS-32| C4 | codons 1-229 | clone C4
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW
>AS-32| C5 | codons 1-229 | clone C5
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQSPEIVI
YQYMDDL*VGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW
>AS-32| C6 | codons 1-229 | clone C6
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW
>AS-32| C7 | codons 1-229 | clone C7
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKISEPFRKQNPEIVV
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW
>AS-32| C8 | codons 1-229 | clone C8
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW
>AS-32| C9 | codons 1-229 | clone C9
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW

References
Author Title Citation
Saah, AJ Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. J Infect Dis, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005