Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-32 | AS-32 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 308 |
| 2 | AZT+DDI | 4 |
| 3 | DDI | 68 |
| 4 | None | 5 |
| 5 | NFV | 36 |
| 6 | DDI+NFV | 14 |
| 7 | D4T+NFV | 5 |
| 8 | D4T+DDI+NFV | 47 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | Q58E, G73S | I13V, K20V, L63P, A71V, V77I |
| >AS-32| codons 1-99 PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVREYD QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-32| C1 | codons 1-99 | clone C1 PQITLWQRPLVTVKIGGQLVEAPLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-32| C2 | codons 1-99 | clone C2 PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-32| C3 | codons 1-99 | clone C3 PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-32| C4 | codons 1-99 | clone C4 PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVREYD QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-32| C5 | codons 1-99 | clone C5 PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVREYD QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-32| C6 | codons 1-99 | clone C6 PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-32| C7 | codons 1-99 | clone C7 PQITLWQRPLVTVRIGGQLVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-32| C8 | codons 1-99 | clone C8 PQITLWQRPLVTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD QIPIEICGHKVIGTVLIGPTPVNIIGRNLMTQIGCTLNF >AS-32| C9 | codons 1-99 | clone C9 PQITLWQRPLVTIKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215Y | K219Q | V60I, K104Q, D121Y, K122E, D177E |
| >AS-32| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW >AS-32| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW >AS-32| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW >AS-32| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIAI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW >AS-32| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW >AS-32| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQSPEIVI YQYMDDL*VGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW >AS-32| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW >AS-32| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKISEPFRKQNPEIVV YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW >AS-32| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW >AS-32| C9 | codons 1-229 | clone C9 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |