Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-30 | AS-30 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+NFV | 96 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | N37S, I62V, L63P, A71T, V77I, I93L |
| >AS-30| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-30| C1 | codons 1-99 | clone C1 PQITLWQRPFVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-30| C2 | codons 1-99 | clone C2 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-30| C3 | codons 1-99 | clone C3 PQITLWQRPFVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTRLGCTLNF >AS-30| C4 | codons 1-99 | clone C4 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLAQLGCTLNF >AS-30| C5 | codons 1-99 | clone C5 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-30| C6 | codons 1-99 | clone C6 PQITL*QRPLVTVKIGGQLKEALLDTGADNTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-30| C7 | codons 1-99 | clone C7 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMSLPGKWKPKVIGGIGGFIKVRQYD QVPIEIRGHKTTGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-30| C8 | codons 1-99 | clone C8 PQITLWQRPFVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | T39K, K43E, K49R, K122E, E169K, K173E, Q207E |
| >AS-30| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWRWGFYTPDKKHQKEPPFLW >AS-30| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVGICKELEEEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEAPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWRWGFYTPDKKHQKEPPFLW >AS-30| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMAKILKPFREQNPDIVI YQYVDDLYVGSGLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLW >AS-30| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEIRKELEEEGKISRIGPGNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKLFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLW >AS-30| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKTSRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIVI YQYVDDLYVGSDLEIGLHRTKIEELRGHLWRWGFHTPDKKHQKEPPFLW >AS-30| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICKELEEEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIAI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLW >AS-30| C6 | codons 1-228 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKVLEEEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFL >AS-30| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDSRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILRPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPEKKHQKEPPFLW >AS-30| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKISRIGPENPYNTPV FAVKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |