<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
AS-30 AS-30 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 3TC+D4T+NFV 96

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N N88D N37S, I62V, L63P, A71T, V77I, I93L  
>AS-30| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF
>AS-30| C1 | codons 1-99 | clone C1
PQITLWQRPFVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVKQYD
QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF
>AS-30| C2 | codons 1-99 | clone C2
PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD
QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF
>AS-30| C3 | codons 1-99 | clone C3
PQITLWQRPFVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVKQYD
QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTRLGCTLNF
>AS-30| C4 | codons 1-99 | clone C4
PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD
QVPIEICGHKTIGTVLIGPTPVNIIGRDLLAQLGCTLNF
>AS-30| C5 | codons 1-99 | clone C5
PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD
QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF
>AS-30| C6 | codons 1-99 | clone C6
PQITL*QRPLVTVKIGGQLKEALLDTGADNTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD
QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF
>AS-30| C7 | codons 1-99 | clone C7
PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMSLPGKWKPKVIGGIGGFIKVRQYD
QVPIEIRGHKTTGTVLIGPTPVNIIGRDLLTQLGCTLNF
>AS-30| C8 | codons 1-99 | clone C8
PQITLWQRPFVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVKQYD
QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y       T39K, K43E, K49R, K122E, E169K, K173E, Q207E  
>AS-30| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLWRWGFYTPDKKHQKEPPFLW
>AS-30| C1 | codons 1-229 | clone C1
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVGICKELEEEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNEAPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLWRWGFYTPDKKHQKEPPFLW
>AS-30| C2 | codons 1-229 | clone C2
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMAKILKPFREQNPDIVI
YQYVDDLYVGSGLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLW
>AS-30| C3 | codons 1-229 | clone C3
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEIRKELEEEGKISRIGPGNPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKLFREQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLW
>AS-30| C4 | codons 1-229 | clone C4
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKTSRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIVI
YQYVDDLYVGSDLEIGLHRTKIEELRGHLWRWGFHTPDKKHQKEPPFLW
>AS-30| C5 | codons 1-229 | clone C5
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICKELEEEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIAI
YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLW
>AS-30| C6 | codons 1-228 | clone C6
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKVLEEEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFL
>AS-30| C7 | codons 1-229 | clone C7
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDSRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILRPFREQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPEKKHQKEPPFLW
>AS-30| C8 | codons 1-229 | clone C8
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKISRIGPENPYNTPV
FAVKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLW

References
Author Title Citation
Saah, AJ Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. J Infect Dis, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005