Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-27 | AS-27 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC+NFV | 64 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | T12A, K14R, I15V, R57K, I62V, L63P, V77I, I93L |
| >AS-27| codons 1-99 PQITLWQRPLVAIRVGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-27| C1 | codons 1-99 | clone C1 PQITLWQRPLVAIRVGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-27| C2 | codons 1-99 | clone C2 PQITLWQRPLVAIRVGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-27| C3 | codons 1-99 | clone C3 PQITLWQRPLVAIRVGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-27| C4 | codons 1-99 | clone C4 PQITLWQRPLVAIRVGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-27| C5 | codons 1-99 | clone C5 PQITLWQRPLGAIRVGGQLKEALLDTGADNAVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-27| C6 | codons 1-99 | clone C6 PQITLWQRPLVAIRVGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-27| C7 | codons 1-99 | clone C7 PQITLWQRPLVAIRVGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V | V106I, I135T, K166R, K173E, Q207E, F214L |
| >AS-27| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW >AS-27| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKGGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFREQNPDIII YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW >AS-27| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKGTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW >AS-27| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKGPPFLW >AS-27| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFREQNPDIII YQYVDDLYVGSDLEIGQHRTKIEELRERLLRWGLTTPDKKHQKEPPFLW >AS-27| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRVLEPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW >AS-27| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEREGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW >AS-27| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRERNPDIII YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |