Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-26 | AS-26 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC+NFV | 52 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | Q61E, I62V, L63P, V77I, I93L |
| >AS-26| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD EVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-26| C1 | codons 1-99 | clone C1 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD EVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-26| C2 | codons 1-99 | clone C2 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD EVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-26| C3 | codons 1-99 | clone C3 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD EVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-26| C4 | codons 1-99 | clone C4 PQITLWQRPLVAIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD EVPIEICGHKAIGTVLIGPIPVNIIGRDLLTQLGCTLNF >AS-26| C5 | codons 1-99 | clone C5 PQITLWQRPLVTIKIGGRLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD EVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF >AS-26| C6 | codons 1-99 | clone C6 PQITLWQRPLVTIKIGGQLRGALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD EVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-26| C7 | codons 1-99 | clone C7 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD EVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-26| C8 | codons 1-99 | clone C8 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD EVPIEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V | K11R, K122E, E169D, G196E, T200I |
| >AS-26| codons 1-229 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-26| C1 | codons 1-229 | clone C1 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-26| C2 | codons 1-229 | clone C2 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-26| C3 | codons 1-229 | clone C3 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-26| C4 | codons 1-229 | clone C4 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYDVLPQGWKGSPAIFQSSMTKILDSFRKQNPDIVI YQYVDDLYVGSDLEIEQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-26| C5 | codons 1-229 | clone C5 PISPIEPVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DGNFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVT YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-26| C6 | codons 1-229 | clone C6 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-26| C7 | codons 1-229 | clone C7 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGSKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-26| C8 | codons 1-229 | clone C8 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |