Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-25 | AS-25 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 37 |
| 2 | AZT+DDC | 123 |
| 3 | DDC | 56 |
| 4 | 3TC+DDI | 19 |
| 5 | None | 4 |
| 6 | D4T+NFV | 40 |
| 7 | D4T+DDI+NFV | 66 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | I13V, E35D, M36I, N37C, I62V, L63P, I72T |
| >AS-25| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDICLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKATGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-25| C1 | codons 1-99 | clone C1 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLGDICLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKATGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-25| C2 | codons 1-99 | clone C2 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDICLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKATGTVLVGPTPVNIIGRDPLTQIGCTLNF >AS-25| C3 | codons 1-99 | clone C3 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDICLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTTGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-25| C4 | codons 1-99 | clone C4 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEMCLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTTGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-25| C5 | codons 1-99 | clone C5 PQIALWQRPLVTVKIGGQLKEALLDTGADNTVLEDICLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKATGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-25| C6 | codons 1-99 | clone C6 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDICLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKATSTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-25| C7 | codons 1-99 | clone C7 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDICLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTTGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-25| C8 | codons 1-99 | clone C8 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDICLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKATGTVLVGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | V35M, I50V, K104N, I135T, I178M |
| >AS-25| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKVGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFLW >AS-25| C1 | codons 1-229 | clone C1 PISPIETVPVKLEPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKVGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYSSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEGLRRHLLRWGFFTPDQKHQKEPPFLW >AS-25| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEEEGKISKVGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFLW >AS-25| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKVGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFSTLDQKHQKEPPFLW >AS-25| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKVGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFLW >AS-25| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKVGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFLW >AS-25| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKVGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFLW >AS-25| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEREGKISKVGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFLW >AS-25| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKVGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMAKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |