Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-22 | AS-22 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 8 |
| 2 | 3TC+D4T | 26 |
| 3 | D4T+DDI+NFV | 78 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | I13V, Q18L, K20R, E35D, M36I, K45Q |
| >AS-22| codons 1-99 PQITLWQRPLVTVKIGGLLREALLDTGADNTVLEDINLPGRWKPQMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-22| C1 | codons 1-99 | clone C1 PQITLWQRPLVTVKIGGLLREALLDTGADNTVLEDINLPGRWKPQMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-22| C2 | codons 1-99 | clone C2 PQITLWQRPLVTVKIGGLLREALLDTGADNTVLEDVNLPGRWKPQMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-22| C3 | codons 1-99 | clone C3 PQITLWQRPLVTVKIGGLLREALLDTGADNTVLEDINLPGRWKPQMIGGIGGFIKVRQYD QVQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-22| C4 | codons 1-99 | clone C4 PQITLWQRPLVTVKIGGQPREALLDTGADNTVLEDINLPGRWRPQMIGGIGGFIKVRQYD QVQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-22| C5 | codons 1-99 | clone C5 PQITLWQRPLVTVKIGGLLREALLDTGADNTVLEDINLPGRWKPQMIGGIGGFIKVRQYD QVQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-22| C6 | codons 1-99 | clone C6 PQITLWQRPLVTVKIGGLLREALLDTGADNTVLEDINLPGRWKPQMIGGIGGFIKVRQYD QVQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-22| C7 | codons 1-99 | clone C7 PQITLWQRPLVTVKIGGLLREALLDTGADNTVLEDINLPGRWKPQMIGGIGGFIKVRQYD QVQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-22| C8 | codons 1-99 | clone C8 PQITLWQRPLVTVKIGGLLREALLDTGADNTVLEDINLPGRWKPQMIGGIGGFIKVRQYD QVQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N | V35I, T39A, R83K, A98S, D123E, D177E, I178V, T200A, Q207E |
| >AS-22| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-22| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQWPLTEGKIKALIEICAEMEKEGKISKIGPESPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNGTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFIW >AS-22| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKISKIGPESPYNTPV FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-22| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-22| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPVTEEKIKALVETCAEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFRKQNPEVVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-22| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-22| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI YQYMDDLYVGSDLEIGQHRAKIKELREHLLRWGFTTPDKKHQKEPPFLW >AS-22| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKISKIEPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLW >AS-22| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |