Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-21 | AS-21 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+AZT | 187 |
| 2 | 3TC+AZT+DDI | 88 |
| 3 | D4T+DDI+NFV | 41 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | I13V, L63P |
| >AS-21| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-21| C1 | codons 1-99 | clone C1 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNVLTQIGCTLNF >AS-21| C2 | codons 1-99 | clone C2 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVIGTVLIGPTPVNIIGRNLSTQIGCTLNF >AS-21| C3 | codons 1-99 | clone C3 PQITLWQRPLVTVKIGGQLEEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNVLTQIGCTLNF >AS-21| C4 | codons 1-99 | clone C4 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-21| C5 | codons 1-99 | clone C5 PQITLWQRPLVTVKIGGQLREALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNVLTQIGCTLNF >AS-21| C6 | codons 1-99 | clone C6 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | V35R, T39A, K43E, E53D, K122E, I135T, S162Y, T200A, R211K |
| >AS-21| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEEEGKISKIGPDNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-21| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEEEGKISKIGPDNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-21| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEEEGKISKIGPDNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-21| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEEEGKISKIGPDNSYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-21| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEEEGKISKIGPDNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLRKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFLW >AS-21| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEEEGKISKIGPDNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVPPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-21| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEEEGKISKIGPDDPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |