Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-20 | AS-20 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 222 |
| 2 | 3TC+AZT | 88 |
| 3 | D4T+DDI+NFV | 52 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | E35D, M36I, L63P |
| >AS-20| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-20| C1 | codons 1-99 | clone C1 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDINLPGRWEPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-20| C2 | codons 1-99 | clone C2 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-20| C3 | codons 1-99 | clone C3 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTILVGPTPVNIIGRNLLTQIGCTLNF >AS-20| C4 | codons 1-99 | clone C4 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-20| C5 | codons 1-99 | clone C5 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-20| C6 | codons 1-99 | clone C6 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >AS-20| C7 | codons 1-99 | clone C7 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLDF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | V60I, V90I, D121H, K122E, I135T, I142V, S162W, V179I, T200I |
| >AS-20| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQWSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRIKIEELRQHLLRWGFYTPDKKHQKEPPFLW >AS-20| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQWSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRIKIEELRQHLWRWGFYTPDKKHQKEPPFLW >AS-20| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMGGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQWSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRIKIEELRQHLLRWGFYTPDKKHQKEPPFLW >AS-20| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQWSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRIKIEELRQHLLRWGFYTPDKKHQKEPPFLW >AS-20| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQWSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRIKIEELRQHLLRWGFYTPDKKHQKEPPFLW >AS-20| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTVPSTNNETPGVRYQYNVLPQGWKGSPAIFQWSMTKILEPFRKQNPDIII YQYMDDLHVGSDLEIGQHRIKIEELRQHLLRWGFYTPDKKHQKEPPFLW >AS-20| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQWSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRIKIEELRQHLLRWGFYTPDKKHQKEPPFLW >AS-20| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQWSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRIKIEELRQHLWRWGFYTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |