Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-19 | AS-19 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC | 54 |
| 2 | 3TC+D4T+NFV | 50 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | A98S, K122A, I135V, S162A, V179I, V189I, R211K |
| >AS-19| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIII YQYVDDLYIGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-19| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILDPFRKQNPDIII YQYVDDLYIGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-19| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDSWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-19| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIII YQYVDDLYIGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-19| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-19| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIII YQYVDDLYIGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-19| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTRDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFRASMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRIKVEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-19| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIII YQYVDDLYIGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-19| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDVII YQYVDDLYIGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-19| C9 | codons 1-229 | clone C9 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTMPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGFYTPDKKHQKEPPFLW >AS-19| C10 | codons 1-229 | clone C10 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWGVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | L63P, I64V, V77I, I93L |
| >AS-19| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-19| C1 | codons 1-99 | clone C1 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-19| C2 | codons 1-99 | clone C2 PQITLWQRPLVTIKIGGQPKEALLDTGADNTVLEEMNLPGRWKPKMIGGVGGFIKVRQYD QIPVEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-19| C3 | codons 1-99 | clone C3 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-19| C4 | codons 1-99 | clone C4 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-19| C5 | codons 1-99 | clone C5 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-19| C6 | codons 1-99 | clone C6 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEVNLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-19| C7 | codons 1-99 | clone C7 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-19| C8 | codons 1-99 | clone C8 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPRRWKPKMIGGIGGFIKVRQYD QIPVEICGPKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-19| C9 | codons 1-99 | clone C9 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF >AS-19| C10 | codons 1-99 | clone C10 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD RIPVEICGHKAIGTVLIGPTPVNIIGRDLLTQLGCTLNF |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |