Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-18 | AS-18 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 65 |
| 2 | AZT+DDI | 30 |
| 3 | AZT | 26 |
| 4 | 3TC+AZT+D4T | 52 |
| 5 | AZT+D4T+NFV | 55 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | I13V, E35D, M36I, R41K, I62V, L63P, A71T |
| >AS-18| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-18| C1 | codons 1-99 | clone C1 PQITLWQRPLVTVKIGGQLREAPLDTGADNTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-18| C2 | codons 1-99 | clone C2 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGIVLVGPTPVNIIGRDLLTQIGCTLNF >AS-18| C3 | codons 1-99 | clone C3 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDINLPGKWRPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-18| C4 | codons 1-99 | clone C4 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-18| C5 | codons 1-99 | clone C5 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDINLPGKWKPKMIGGIGGFIKIRQYD QVPIEICGHKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-18| C6 | codons 1-99 | clone C6 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLVGPTPVNIIGRDLLTQIGRTLNF >AS-18| C7 | codons 1-99 | clone C7 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDINLTGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-18| C8 | codons 1-99 | clone C8 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDINLPGKWKSKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF >AS-18| C9 | codons 1-99 | clone C9 PQITLWQRPLVTVKIGGQLREALLDTGADNTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | A98G | V35M, R83K, K122E, R211K |
| >AS-18| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-18| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVRQWPLTEEKIKALMEICTELEKEGKISKIGPEYPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-18| C2 | codons 1-229 | clone C2 PISPIETVPVNLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRNQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-18| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYYTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-18| C4 | codons 1-229 | clone C4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKGGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSITNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-18| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKITALMEICTELEKGGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNRKTQDFWEVQLGISHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPSLW >AS-18| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNGLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRRHLWKWGFYTPDKKHQKEPPFLW >AS-18| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-18| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVGFRELNKKTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLW >AS-18| C9 | codons 1-229 | clone C9 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPGGLKK*KSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLGKWGFYTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |