Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AS-16 | AS-16 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 129 |
| 2 | None | 233 |
| 3 | 3TC+D4T | 2 |
| 4 | 3TC+D4T+NFV | 65 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | E35D, M36I, N37S, L63P, A71T, V77I |
| >AS-16| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDISLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF >AS-16| C1 | codons 1-98 | clone C1 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDISLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPANIIGRDLLTQIGCTLN >AS-16| C2 | codons 1-99 | clone C2 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMCLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF >AS-16| C3 | codons 1-99 | clone C3 PRITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEMCLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTIGTVLIGPTPVNIIGRDLLAQIGCTLNF >AS-16| C4 | codons 1-99 | clone C4 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDISLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF >AS-16| C5 | codons 1-99 | clone C5 PQITLWRRPPVTIKIGGQLKEALLDTGADNTVLEEMCLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF >AS-16| C6 | codons 1-99 | clone C6 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDMSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF >AS-16| C7 | codons 1-99 | clone C7 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDVSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPVNIIGRDLLTQIGCTLNF >AS-16| C8 | codons 1-99 | clone C8 PQITLWQRPLVTIKIGGQPKEALLDTGADNTVLEDVSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | K122E, I135V |
| >AS-16| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-16| C1 | codons 1-229 | clone C1 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFGELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSNMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKIKELRQHLLRWGFTTPDKKHQKEPPFLW >AS-16| C2 | codons 1-229 | clone C2 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALAEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKHTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-16| C3 | codons 1-229 | clone C3 PISPIETVPVKLKPGTDGPKVKQGPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFGKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-16| C4 | codons 1-229 | clone C4 PISPIGTVPVKLRPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGGAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPRGWKGSPAIFQNSMTKILGPFRKQSPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-16| C5 | codons 1-229 | clone C5 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAVKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNEIPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-16| C6 | codons 1-229 | clone C6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKTSKIGPENPYNTPA FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >AS-16| C7 | codons 1-229 | clone C7 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >AS-16| C8 | codons 1-229 | clone C8 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVT YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Saah, AJ | Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | J Infect Dis, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |