Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1392 | CA3645 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC+ AZT | 69 |
| 2 | AZT+ 3TC | 56 |
| 3 | RTV+ AZT+ 3TC | 43 |
| 4 | SQV+ RTV+ AZT+ 3TC | 17 |
| 5 | SQV+ NFV+ D4T+ 3TC | 21 |
| 6 | NVP+ DDI+ D4T | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10V, I15V, L19V, E35D, M36I, D60E, Q61D, L63P, A71V |
| >CA3645| codons 1-99 PQITLWQRPVVTIKVGGQVKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVRQYE DIPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, K70R, T215F | K219E | K103N, Y181YC, G190GA | V35Q, T39A, S68SG, D123E, I135T, I142V, K166R, D177E, V179X, G196E, E203D, A272P, K277R |
| >CA3644| codons 1-280 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALQEICAELEKEGKISKIGPENPYNTPV FAIKKKNGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIXI CQYMDDLYVASDLEIEQHRTKIDELRQHLLRWGFFTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLC |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |