<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TVGG38 TVGG38 Brazil 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 43
2 AZT+DDI 9
3 3TC+AZT 52
4 3TC+AZT+RTV 9
5 3TC+AZT+IDV 22
6 Unknown 52
7 3TC+D4T+NFV 35

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L10F, I50F I15V, L63P, L89I  
>TVGG38| codons 1-99
PQITLWQRPFVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGFGGFVKVRQYD
QIPIEICGHKAIGTVLVGPTPANIIGRNILTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184V, L210W, T215Y K219N K103N, Y181I   E44D, K64N, V118I, K122E, I135T, D177E, T200A, H208Y, R211K, V245T, A272S, R284K, T286A, A288G, I293V, P294T, P313T, V317A  
>TVGG38| codons 1-324
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV
FAINKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
IQYVDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLKGAKGLTEVVTLTEEAE
LELAENREILKETVHGAYYDPSKD

References
Author Title Citation
Brindeiro, PA Testing genotypic and phenotypic resistance in human immunodeficiency virus type 1 isolates of clade B and other clades from children failing antiretroviral therapy. J Clin Microbiol, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005