Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TVSP3 | TVSP3 | Brazil | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 9 |
| 2 | Unknown | 11 |
| 3 | 3TC+AZT+RTV | 22 |
| 4 | 3TC+D4T+RTV | 38 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12K, I15V, E35D, N37E, K43R, V82I |
| >TVSP3| codons 1-99 PQITLWQRPLVKIKVGGQLKEALLDTGADDTVLEDMELPGRWRPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPINIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | T27P, I135T, S162G, F214L, V245M, A272P, I293V | D185N |
| >TVSP3| codons 1-320 PISPIETVPVKLKPGMDGPKVKQWPLPEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQGSMTKILEPFRKQNPDIVI YQYVNDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYD |
References
| Author | Title | Citation |
| Brindeiro, PA | Testing genotypic and phenotypic resistance in human immunodeficiency virus type 1 isolates of clade B and other clades from children failing antiretroviral therapy. | J Clin Microbiol, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |