Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TVSP2 | TVSP2 | Brazil | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 92 |
| 2 | 3TC+AZT | 31 |
| 3 | 3TC+D4T+RTV | 72 |
| 4 | D4T+NFV+NVP | 11 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V106A, Y181C | V35M, T39A, E40D, S68G, D121H, K122E, D123S, I178L, R211K, F214L, V245E, A272P, K277R, T286A, I293V, E297K |
| >TVSP2| codons 1-319 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADMEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSVPL HESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYY |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L10I, K20R, E35Q, M36I, N37D, R41K, D60E, L63P, A71V, I72V |
| >TVSP2| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEQIDLPGKWKPKMIGGIGGFVKVRQYE QIPIEICGHKVVGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Brindeiro, PA | Testing genotypic and phenotypic resistance in human immunodeficiency virus type 1 isolates of clade B and other clades from children failing antiretroviral therapy. | J Clin Microbiol, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |