<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
GART-NG118 GART-118 U.S. 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 Unknown NA
2 DDI+ 3TC+ NFV NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I   L10V, K20T, R41K, D60E, I62IV, I64V, K70T, T74S, V77I, I93L L63K
>GART-118| codons 1-99
PQITLWQRPVVTIKIGGQLTEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYE
QVKVEICGHTAIGSVLIGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, T215Y   K101KE, Y181C P225H E28K, K32E, D123E, I135V, S162C, D177E, I178M, V179I, Q207E, R211K, V245T  
>GART-118| codons 1-250
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEMII
CQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFYTPDKKHQKEHPFLWMGYELHPDKWT
VQPITLPEKD

References
Author Title Citation
Baxter, JD A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 study team for the Terry Beirn community programs for clinical research on AIDS. AIDS, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005