<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
GART-G93 GART-93 U.S. 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI+ NRTI NA
2 D4T+ 3TC+ NFV NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, T215Y       T39A, E40EQ, A98S, T107P, K122E, I142V, D177E, T200A, E203X, R211K  
>GART-93| codons 1-250
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAQLEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVPVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYVDDLYVGSDLEIGQHRAKIXELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N N88D L10I, I13IV, T31TP, N37S, L63P, I64V, T74S, V77I, I93L, N98K  
>GART-93| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADNPVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QIPVEICGHKAIGSVLIGPTPVNIIGRDLLTQLGCTLKF

References
Author Title Citation
Baxter, JD A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 study team for the Terry Beirn community programs for clinical research on AIDS. AIDS, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005