<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
GART-G88 GART-88 U.S. 1997 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI+ NRTI NA
2 AZT+ 3TC+ IDV NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KR, M184V, L210W, T215Y K219KE   A98G K173Q, I178L, R211K, K223KR, V245M, E248Q, A272P, I293V, E297Q N265NS, Y271YD
>GART-88| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQQNPDLVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDEKHQREPPFLWMGYELHPDKWT
VQPIMLPQKDSWTVNDIQKLVGKLSWASQIDPGIKVKQLCKLLRGTKALTEVVPLTQEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54IV, V82VA, I84IV L24LI, Q58QE L10LI, E35D, M46X, L63P, A71V, I85IV, I93IL  
>GART-88| codons 1-99
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEDMNLPGRWKPKXIGGIGGFVKVREYD
QIPIEICGHKVIGTVLVGPTPANVVGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 study team for the Terry Beirn community programs for clinical research on AIDS. AIDS, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005