Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DR50 | DR50 | South Africa | 2002 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+ EFV+ D4T | NA |
| 2 | 3TC+ AZT+ EFV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103N, V106M | P4S, E6K, V35T, E36A, T39E, S48T, V90VI, V118I, K122E, I135IL, E138A, T165I, K173I, Q174K, D177DE, T200A, Q207E, R211K, F214L, V245K, D250E, A272P, K277R, T286A, E291D, V292I, I293V |
| >DR50| codons 1-333 PISSIKTVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSMTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNATPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRIKNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, K14R, I15V, L19I, E35D, M36MI, R41K, R57RK, D60E, Q61E, H69K, L89M, I93L |
| >DR50| codons 1-99 PQITLWQRPLVSIRVGGQIKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYE EILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Pillay, V | HIV type 1 subtype C drug resistance among pediatric and adult South African patients failing antiretroviral therapy. | ARHR, 2008 |