<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DR50 DR50 South Africa 2002 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 DDI+ EFV+ D4T NA
2 3TC+ AZT+ EFV NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   K103N, V106M   P4S, E6K, V35T, E36A, T39E, S48T, V90VI, V118I, K122E, I135IL, E138A, T165I, K173I, Q174K, D177DE, T200A, Q207E, R211K, F214L, V245K, D250E, A272P, K277R, T286A, E291D, V292I, I293V  
>DR50| codons 1-333
PISSIKTVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSMTVLDVGDAYFSIPL
DEDFRKYTAFTIPSLNNATPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRIKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, K14R, I15V, L19I, E35D, M36MI, R41K, R57RK, D60E, Q61E, H69K, L89M, I93L  
>DR50| codons 1-99
PQITLWQRPLVSIRVGGQIKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYE
EILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Pillay, V HIV type 1 subtype C drug resistance among pediatric and adult South African patients failing antiretroviral therapy. ARHR, 2008