Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DR48 | DR48 | South Africa | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ NFV+ DDI+ EFV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I | L10I, I15V, N37C, I62V, L63P, A71V, I72V, I93L |
| >DR48| codons 1-99 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEEMCLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVVGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, Q151M, T215Y | V75I, F116Y, K219E | Y181YC, G190S | V35M, S48T, K122E, Q197QE, T200E, Q207K, R211A, L228LH, L283I, I293V, S322T, I329V |
| >DR48| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKITKIGPENPYNTPV FAIKKKNSTRWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVSSDLEIGEHREKIEELRKHLLAWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEVQKQGQG |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |