Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4127 | CA35193 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T | 69 |
| 2 | 3TC+D4T+IDV | 61 |
| 3 | 3TC+D4T+NFV+NVP | 31 |
| 4 | 3TC+D4T+NFV+RTV+SQV | 69 |
| 5 | 3TC+ABC+APV | 83 |
| 6 | 3TC+D4T+LPV | 35 |
| 7 | 3TC+AZT | 63 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | A62AV, V75I | K103N, Y181YC | I31L, V35T, A98S, D123E, Q174QR, I178L, V179I, Q207E, R211K, L228H |
| >CA35193| codons 1-244 PISPIETVPVKLKPGMDGPKVKQWPLTEEKLKALTEICTELEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDLII CQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | V11I, F53FL, Q58QE | L10I, I13V, I15V, K20I, K55R, L63P, A71I, Q92QR |
| >CA34185| codons 1-99 PQITLWQRPIITVKVGGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGLMRVREYD QIPIEICGHKIIGTVLVGPTPVNVIGRNLMTRIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |