Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7988 | CA35156 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 83 |
| 2 | D4T+DDI+NFV | 196 |
| 3 | DDI+EFV+LPV | 35 |
| 4 | DDI+LPV+NVP | 31 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74V | T215TI, K219Q | K103N | V108I, K238T | K20R, V35IM, T39A, V60I, K64H, T69N, S105A, I135T, E138A, I202V, F214L, H221Y, L228H, T286A, I293V |
| >CA35156| codons 1-299 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAEMEKEGKISKIGPENPYNTPI FAIHKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKAVTILDVGDAYFSVPL DKDFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKVEELRQHLLRWGLITPDQKYQKEPPFHWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L10F, L24I | T12P, K14R, K20KR, L63P, A71V, I93L |
| >CA34142| codons 1-99 PQITLWQRPFVPIRIGGQLREALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |