Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5481 | CA35121 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 109 |
| 2 | AZT+DDC | 65 |
| 3 | AZT+DDC+SQV | 65 |
| 4 | D4T+DDI+NFV+NVP | 4 |
| 5 | D4T+DDI+NFV | 35 |
| 6 | 3TC+AZT+IDV+RTV | 131 |
| 7 | 3TC+ABC+EFV | 48 |
| 8 | ABC+D4T+EFV | 55 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74LI, L210LW, T215F | K219HQ | Y188L | T39N, E44D, V60I, V118VI, K122E, I135L, T139I, I195IL, E203EK, Q207AE, L228H, K238X, K277R, T286A, E297K |
| >CA35121| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICNELEKDGKISKIGPENPYNTPI FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNEIPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLELGQHRTKIKELRAHLWRWGFFTPDHKHQKEPPFHWMGYELHPDXWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVIPLTKEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GV, I54IT, V82VA | L10LI, N37NT, I62IV, I64V, A71AV, T74TS, V77VI |
| >CA34106| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMTLPGRWKPKMIVGIGGFTKVRQYD QVLVEICGHKVIGSVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |