Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4398 | CA35046 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+DDC | 25 |
| 2 | 3TC+D4T+IDV | 72 |
| 3 | 3TC+D4T+RTV+SQV | 76 |
| 4 | APV+D4T+DDI+NVP+RTV | 38 |
| 5 | ABC+D4T+IDV+RTV | 37 |
| 6 | 3TC+D4T+LPV | 93 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W | T215D | K103KN, Y181C | E6EK, S68G, K122E, I135T, S162A, I178IM, Q207E, R211K, A272P, I293V | K220KIRT |
| >CA35046| codons 1-300 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDMVI CQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFDTPDKTHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L10I, R41K, K43R, I62V, L63P, H69Y, A71T, I72E, V77VI, I93L |
| >CA34034| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWRPKMIGGIGGFIKVRQYD QVPIEICGYKTEGTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |