Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1169 | CA35001 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 226 |
| 2 | AZT+DDC | 35 |
| 3 | 3TC+AZT | 44 |
| 4 | 3TC+AZT+SQV | 22 |
| 5 | 3TC+AZT+NVP | 17 |
| 6 | 3TC+D4T+NFV | 15 |
| 7 | 3TC+D4T+RTV+SQV | 37 |
| 8 | 3TC+D4T | 36 |
| 9 | 3TC+D4T+IDV | 191 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, V75M, M184V, L210W, T215Y | D67G, F77L | K101EQ | T39TA, A98S, V118I, K122E, I135IT, A158S, T286A, E297K |
| >CA35001| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKGSDKWRKLMDLRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | K43T | L10I, I62V, L63P, A71V, I72E, I93L |
| >CA33986| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWTPKIIGGIGGFVKVRQYD QVPIEICGHKVEGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |