Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4743 | CA34921 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC | 78 |
| 2 | 3TC+D4T+IDV | 126 |
| 3 | 3TC+D4T+IDV+RTV | 26 |
| 4 | 3TC+D4T+NFV | 100 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, K70R, M184V, T215F | D67G | T7TA, K20KR, T39TA, S68G, I135T, S162Y, Q174H, I178IM, Q207E, L228X, A272P, A288S |
| >CA34921| codons 1-288 PISPIEAVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKGGDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKHNPDMVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGFFTPDKKHQKEPPFXWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKS |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A, L90M | L10FI, K43T | L19I, N37NS, K55R, L63P, H69Q, A71V, I72IV |
| >CA33906| codons 1-99 PQITLWQRPFVTIKIGGQIKEALLDTGADDTILEEMSLPGRWTPKIIGGIGGFIRVRQYD QIPIEICGQKVVGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |