Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA14548 | CA34918 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 26 |
| 2 | 3TC+AZT | 35 |
| 3 | 3TC+AZT+IDV | 13 |
| 4 | 3TC+AZT+RTV | 35 |
| 5 | 3TC+AZT+NFV | 78 |
| 6 | D4T+DDI+EFV | 178 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, T215Y | K103N, Y181C, G190A | A98G, V108I | T7TA, V35M, T39X, K43KE, E44D, I50IV, W88WC, K122KE, D123E, R172RK, D177E, I178L, V189VI, G196E, E203K, Q207E, H208Y, R211K, A272P, V276T, K277R, I293V, E297K | K223D |
| >CA34918| codons 1-301 PISPIEAVPVKLKPGMDGPKVKQWPLTEEKIKALMEICXELEEDGKISKVGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFCEVQLGIPHPGGLKKNKSVTILDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPELVI CQYMDDLYIASDLEIEQHRTKIKELREYLLKWGFYTPDKKHQDEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCKLLRGTKALTEVVPLTKEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V | K20I, E34Q, M36MI, K43KR, K45R, I62V, L63P, A71V, I93L | C95CY |
| >CA33903| codons 15-99 IGGQLIEALLDTGADDTVLQEINLPGRWRPRMIGGIGGFIKVRQYDQVPIEICGHKVIGT VLVGPTPVNVIGRNLLTQLGYTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |