Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6585 | CA34872 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 6 |
| 2 | D4T+DDI+RTV+SQV | 17 |
| 3 | ABC+EFV+NFV+NVP | 41 |
| 4 | 3TC+APV+AZT+RTV | 37 |
| 5 | 3TC+D4T+LPV+NVP | 76 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | Y188L | A98G | S3A, K20KR, V35I, T39A, K43Q, E44D, V118I, K122E, I135T, V179VI, G196E, T200A, E203K, Q207E, H208Y, R211K, K223Q, V245E, A272P, T286A, I293V, E297KR |
| >CA34872| codons 1-300 PIAPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLLVGSDLEIEQHRAKIKELREYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTREAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | L33F, K43T, G73S, L89V | L10V, T12DV, I13V, I15V, K20M, D60E, Q61D, I62V, L63P, C67Y, H69K, A71I, I72L, V77I |
| >CA33857| codons 1-99 PQITLWQRPVVDVKVGGQLMEALLDTGADDTIFEEMNLPGRWTPKIVGGIGGFMKVRQYE DVPIEIYGKKILSTVLIGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |