Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
CA5735 | CA34844 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | 30 |
2 | D4T | 52 |
3 | AZT+3TC | 13 |
4 | AZT+3TC+IDV | 69 |
5 | D4T+NFV+NVP | 65 |
6 | D4T+NVP+RTV | 71 |
7 | AZT+3TC+RTV+IDV | 130 |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41ML, T69DN, K70KR, M184V, T215F | K101E, Y181V | K20KR, T27S, E28K, K32E, V60I, R83K, V179I, T200A, Q207D, L228R, V245E, T286A, E297K |
>CA34844| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLSKEKIEALVEICTELEKEGKISKIGPENPYNTPI FAIKKKDSDRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII VQYVDDLYVGSDLEIGQHRAKIEELRDHLLRWGFFTPDKKHQKEPPFRWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE L |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
I54V, L90M | E35D, M36I, R41K, R57K, L63P, A71V, I72V, I93L |
>CA33837| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVKQYD QIPIEICGHKVVGTVLVGPTPVNIIGRNLMTQLGCTLNF |
References
Author | Title | Citation |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |
Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |