Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1456 | CA34842 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 30 |
| 2 | AZT+DDC | 43 |
| 3 | 3TC+D4T | 31 |
| 4 | 3TC+AZT | 13 |
| 5 | 3TC+AZT+SQV | 22 |
| 6 | 3TC+AZT+IDV | 65 |
| 7 | 3TC+AZT+NFV | 9 |
| 8 | 3TC+AZT+NVP | 44 |
| 9 | D4T+IDV+RTV | 42 |
| 10 | ABC+APV+D4T+RTV+SQV | 158 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | Y188L | P4PS, V35I, T39A, E44D, V60I, V118I, K122E, I135T, S162C, E203K, R211K, K223E, L228R, A272P, E312EK, G333E, Q334V, M357T, T369A, A371V, K390R, K395R, E399D, T403M, E413D, S468P, L491S, K512R, K558R |
| >CA34842| codons 1-560 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRTKIKELRQHLWKWGFYTPDNKHQEEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKKPVHGVYYDPSKDLIAEIQKQEVGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLAEVVQKIATESIVIWGKTPKFRLPIQRETWDAWWMEYWQATWIPDWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTDTTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVSQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRRVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | G73T | L10I, E35D, N37S, L63P, I64V, I66V, A71V, I93L |
| >CA33835| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFLKVRQYD QIPVEVCGHKVITTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |