<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
GFKZB124 GFKZB124 South Africa 2014 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+NVP+TDF 159

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Y115YF, M184V   V106M, Y181C K101HQ, F227L K20R, V35T, T39E, S48T, V60I, S68SN, W88WC, D121H, K122E, I135KR, S163T, T165I, K173T, D177E, T200A, I202V, Q207R, R211K, V245K, A272P, K275KQ, R284K, E291D, V292I, I293V, E297K, D324E, E328D, G335D, R356K, M357R, G359T, T377M, T386I, K390R, A400T, E404D, I434M, V435A  
>GFKZB124| codons 1-440
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI
FAIKRKDNTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLQKKKSMTVLDVGDAFFSVPL
HEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSTMIKILEPFRTQNPEIVI
CQYVDDLYVGSDLEIGQHRAKVEELRRHLLKWGFTTPDKKHQKEPPLLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIQVKQLCKLLKGTKALTDIVPLTKEAE
LELAENREILKEPVHGVYYDPSKELIADIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKIAMESIVIWGKIPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPMAGAETF

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, L19V, E35D, N37S, R41K, R57K, L63V, I64L, H69K, V82I, L89M, I93L  
>GFKZB124| codons 1-99
PQITLWQRPLVSIKIGGQVKEALLDTGADDTVLEDMSLPGKWKPKMIGGIGGFIKVKQYD
QIVLEICGKKAIGTVLVGPTPINIIGRNMLTQLGCTLNF

References
Author Title Citation
Steegen, K HIV-1 antiretroviral drug resistance patterns in patients failing NNRTI-based treatment: results from a national survey in South Africa. J Antimicrob Chemother, 2016