<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
GFKZB285 GFKZB285 South Africa 2014 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+EFV+TDF 44

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, M184V V75M K101E, V106M, Y181C F227L T27S, V35IM, T39E, S48T, S68SN, K122E, D123S, I135R, S162C, K173T, D177E, V179VI, T200A, E203K, Q207E, R211K, V245Q, A272P, T286A, E291D, V292I, K311R, D324E, Q334N, G335D, R356K, M357R, R358K, G359S, T377R, K390R, A400T, E404D, V435A, A437V  
>GFKZB285| codons 1-440
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALMEICEEMEKEGKITKIGPENPYNTPV
FAIKRKDNTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSMTVLDVGDAYFSVPL
DESFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTQNPEIII
CQYVDDLYVGSDLEIGQHRAKIKELREHLLKWGFTTPDKKHQKEPPLLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIIPLTEEAE
LELAENREILREPVHGVYYDPSKELIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKRKSA
HTNDVKQLTEAVQKIARESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGVETF

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, K20KR, E35D, M36I, R41K, Q61E, L63T, H69K, T74A, L89M, I93L  
>GFKZB285| codons 1-99
PQITLWQRPLVSIKVGGQIREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
EITIEICGKKAIGAVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Steegen, K HIV-1 antiretroviral drug resistance patterns in patients failing NNRTI-based treatment: results from a national survey in South Africa. J Antimicrob Chemother, 2016